Step 1
The therapeutic dosage range for LDN is from 1.75mg to 4.5mg every night. Dosages below this range are likely to have no effect at all, and dosages above this range are likely to block endorphins for too long a period of time and interfere with its effectiveness.
Ideal dosage when treating most illnesses is 4.5mg, however many people prefer to start with the lower 3.0mg dosage. It is recommended that those with Multiple Sclerosis begin with 3.0mg and slowly work up to 4.5mg, since starting at the higher dosage may cause some side effects like minor sleep disturbance.
If you have spacicity, it is a good idea to start as low as 1.5mg per night, as the first flush on Naltrexone can increase the spacicity for up to two weeks. Don't increase your dose until the stiffness starts to subside.
Step 2
Begin by taking 3.0mg each night before going to bed, whether using compounded tablets or liquid LDN. Continue taking 3.0mg for 1-4 weeks. If you experience side effects of hyperness, or sleep disturbances, do not increase the dosage until side effects disappear. The usual adult dosage is 4.5mg taken once daily at night. Because of the rhythms of the body's production of master hormones, LDN is best taken between 9pm and 3am. Most patients take it at bedtime.
Step 3
When side effects subside, increase dosage to 3.5mg each night. Continue for 1-4 weeks, then increase to 4.0mg for 1-4 weeks, finally, increase to 4.5mg and maintain this dosage.
Step 4
Keep a symptom log. Track all MS symptoms and LDN side effects, so you can see at a glance how the low dose naltrexone effects you. When you start feeling better it is easy to forget just how sick you were. A written log is a great help.
Step 5
Talk to your doctor or pharmacist about each dosage increase. If you do not have a doctor to help, there is a great deal of experience and wisdom on the LowDoseNaltrexone Yahoo Newsgroup.